Interactions between sialoadenectomy and capsaicin-sensitive afferent fibers on gastric acid secretion in rats.
Life Sci
; 48(7): PL37-41, 1991.
Article
en En
| MEDLINE
| ID: mdl-1990233
ABSTRACT
In this study we have investigated the relative influence of capsaicin-sensitive afferents and sialoadenectomy on gastric acid secretion. Sialoadenectomized (SALX) rats showed a decrease in gastric acid secretion and an increase in gastric calcitonin gene-related peptide-like immunoreactivity (CGRP-li) as compared to sham-operated animals. Capsaicin pretreatment (50 + 100 mg kg-1 in two days) markedly decreased gastric CGRP-li in both sham and SALX-operated rats and increased acid concentration and output only in SALX animals. In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion. Gastric content of vasoactive intestinal polypeptide (VIP)-li was unaffected in SALX and capsaicin-treated rats. Capsaicin-sensitive afferents and EGF contained in the salivary glands may interact in the regulation of the gastric acid secretion.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema Digestivo
/
Ácido Gástrico
/
Neuronas Aferentes
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia