Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Bioorg Med Chem Lett
; 20(3): 1114-7, 2010 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-20031410
ABSTRACT
Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT(1A) partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery of a novel chemical series with a favorable NRI and 5-HT(1A) partial agonist pharmacological profile as well as excellent selectivity for the norepinephrine transporter over the dopamine transporter.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Diseño de Fármacos
/
Agonistas de Receptores de Serotonina
/
Inhibidores de Captación Adrenérgica
/
Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática
/
Agonistas del Receptor de Serotonina 5-HT1
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos