Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.
Appl Opt
; 49(2): 142-52, 2010 Jan 10.
Article
en En
| MEDLINE
| ID: mdl-20062500
ABSTRACT
We report a probe-based portable and clinically compatible instrument for the spectral diagnosis of melanoma and nonmelanoma skin cancers. The instrument combines two modalities--diffuse reflectance and intrinsic fluorescence spectroscopy--to provide complementary information regarding tissue morphology, function, and biochemical composition. The instrument provides a good signal-to-noise ratio for the collected reflectance and laser-induced fluorescence spectra. Validation experiments on tissue phantoms over a physiologically relevant range of albedos (0.35-0.99) demonstrate an accuracy of close to 10% in determining scattering, absorption and fluorescence characteristics. We also demonstrate the ability of our instrument to collect in vivo diffuse reflectance and fluorescence measurements from clinically normal skin, dysplastic nevus, and malignant nonmelanoma skin cancer.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Refractometría
/
Neoplasias Cutáneas
/
Espectrometría de Fluorescencia
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Humans
Idioma:
En
Revista:
Appl Opt
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos