Generation of T cells with lytic specificity for atypical antigens. II. A novel antigen system in the rat dependent on homozygous expression of major histocompatibility complex genes of the class I-like RT1C region.
J Exp Med
; 173(4): 833-9, 1991 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-2007854
ABSTRACT
Lymphocytes from parental strain DA rats can induce potent killer cell responses to atypical antigen systems in F1 Lewis (L)/DA and DA/L recipients. Here, we describe an antigen system, H, present on homozygous parental target cells, but not on F1 cells. This antigen system is unusual in several respects it does not involve class I RT1A gene products usually used by killer cell responses in the rat, it maps to the major histocompatibility complex (MHC) class I-like RT1C region, and it requires homozygous expression of RT1Cav1 alleles. This may be another example, this time involving the RT1C region, of an MHC gene product antigenically altered by an MHC-linked trans-activating modifier gene.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ratas Endogámicas
/
Linfocitos T Citotóxicos
/
Antígenos de Histocompatibilidad Clase I
/
Complejo Mayor de Histocompatibilidad
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1991
Tipo del documento:
Article