The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule.
J Exp Med
; 173(4): 913-21, 1991 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-2007857
ABSTRACT
The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant laboratory rat strains PVG.R1 and PVG.R8 display unusually long retention of RT1.Aa within the endoplasmic reticulum or cis-Golgi. In appropriate F1 hybrid cells heterozygous for RT1.Aa and another class I MHC allele, RT1.Ac, only the RT1.Aa protein is subject to slow transport. The cim gene product therefore shows class I allele specificity in its action, cim appears to be a polymorphic locus whose product is directly involved in the processes of class I MHC assembly and/or intracellular transport.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Antígenos de Histocompatibilidad Clase I
/
Complejo Mayor de Histocompatibilidad
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido