Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.
Opt Lett
; 35(7): 1088-90, 2010 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-20364226
ABSTRACT
Optical projection tomography is a new ex vivo imaging technique that allows imaging of whole organs in three dimensions at high spatial resolutions. In this Letter we demonstrate its capability to tomographically visualize molecular activity in whole organs of mice. In particular, eosinophil activity in asthmatic lungs is resolved using a Born-normalized fluorescence optical projection tomography and employing a near-IR molecular probe. The possibility to achieve molecularly sensitive imaging contrast in optical projection tomography by means of targeted and activatable imaging reporter agents adds a new range of capabilities for investigating molecular signatures of pathophysiological processes and a wide variety of diseases and their development.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Técnicas de Sonda Molecular
/
Tomografía Óptica
/
Microscopía Fluorescente
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Opt Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos