YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli.
J Bacteriol
; 192(13): 3329-36, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20418396
ABSTRACT
Colicin E2-tolerant (known as Cet2) Escherichia coli K-12 mutants overproduce an inner membrane protein, CreD, which is believed to cause the Cet2 phenotype. Here, we show that overproduction of CreD in a Cet2 strain results from hyperactivation of the CreBC two-component regulator, but CreD overproduction is not responsible for the Cet2 phenotype. Through microarray analysis and gene knockout and overexpression studies, we show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Colicinas
/
Proteínas de Escherichia coli
/
Escherichia coli K12
Idioma:
En
Revista:
J Bacteriol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido