DNA methylation and mutator genes in Escherichia coli K-12.
Mutat Res
; 705(2): 71-76, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20471491
ABSTRACT
Mutator strains of Escherichia coli have been used to define mechanisms that account for the high fidelity of chromosome duplication and chromosome stability. Mutant strains defective in post-replicative mismatch repair display a strong mutator phenotype consistent with a role for correction of mismatches arising from replication errors. Inactivation of the gene (dam) encoding DNA adenine methyltransferase results in a mutator phenotype consistent with a role for DNA methylation in strand discrimination during mismatch repair. This review gives a personal perspective on the discovery of dam mutants in E. coli and their relationship to mismatch repair and mutator phenotypes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN Bacteriano
/
Metiltransferasa de ADN de Sitio Específico (Adenina Especifica)
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Metilación de ADN
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Escherichia coli
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Genes Bacterianos
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Metilnitronitrosoguanidina
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Mutación
Idioma:
En
Revista:
Mutat Res
Año:
2010
Tipo del documento:
Article