ProCGlobal and endogenous thrombin potential during pregnancy.
Am J Obstet Gynecol
; 203(5): 463.e1-6, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20598285
ABSTRACT
OBJECTIVE:
Pregnancy is a hypercoagulable state. We evaluated global markers of coagulation activation, ProCGlobal (Siemens Healthcare Diagnostics, Eschborn, Germany) and endogenous thrombin potential (ETP), in pregnant women with and without low-molecular-weight (LMW) heparin prophylaxis. STUDYDESIGN:
We prospectively followed 113 healthy women and 61 women receiving LMW heparin prophylaxis throughout pregnancy. ProCGlobal and ETP were measured in venous blood during the first, second, and third trimester.RESULTS:
ProCGlobal decreased significantly throughout pregnancy in all women and was lower in anticoagulated women (P < .001 for all comparisons). ETP levels remained unchanged until the third trimester and then significantly decreased in all women. ETP was higher in anticoagulated women than in healthy women at all time points.CONCLUSION:
ProCGlobal levels decrease throughout pregnancy. In pregnant women at high thrombotic risk, coagulation activation reflected by low ProCGlobal and high ETP levels is substantial despite LMW heparin prophylaxis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Hematológicas del Embarazo
/
Coagulación Sanguínea
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Proteína C
/
Trombina
/
Trombofilia
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Austria