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Interindividual, repositioning, and time-of-day effects on single voxel proton MR spectroscopy of the anterior cingulate cortex.
Soreni, Noam; Noseworthy, Michael D; Konyer, Norman B; Pullenayegum, Eleanor; Schachar, Russell.
Afiliación
  • Soreni N; Psychiatry Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada.
J Magn Reson Imaging ; 32(2): 276-82, 2010 Aug.
Article en En | MEDLINE | ID: mdl-20677251
ABSTRACT

PURPOSE:

To measure interindividual, repositioning, and time-of-day effects of single voxel PRESS (Point RESolved Spectroscopy) proton magnetic resonance spectroscopy ((1)H-MRS) acquisition of the anterior cingulate cortex (AC) in healthy human subjects. MATERIALS AND

METHODS:

AC (1)H-MRS measurements were performed in 15 healthy adult volunteers using a short echo PRESS sequence (GE Healthcare 3 Tesla, TE/TR = 30/2500 ms, 192 acquisitions, 6 cm(3) voxels). For each individual, a total of eight spectra were obtained during two identical scanning sessions separated by 3.5 h. In each, two consecutive AC spectra were acquired. After the first two scans, the subject left the scanner, then immediately returned for repositioning and acquisition of two more consecutive spectra. The subject then left the imaging centre to return 3.5 h later for a repeated procedure. Spectroscopic postprocessing was done using LCmodel. Interindividual, repositioning and time-of-day effects were measured using restricted maximum likelihood (REML) models of variance components analysis, where response variables were levels of creatine/phosphocreatine (Cr), N-acetyl-aspartate (NAA), myo-inositol (mI), choline (Cho), and the glutamate-glutamine complex (Glx).

RESULTS:

Interindividual effects were markedly higher than time-of-day and repositioning effects for all metabolites.

CONCLUSION:

Our findings show that (1)H-MRS measurements of the AC are sensitive to interindividual differences, while time of day and repositioning are markedly less important.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Giro del Cíngulo Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2010 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Giro del Cíngulo Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2010 Tipo del documento: Article País de afiliación: Canadá