Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart.
Prostaglandins Leukot Essent Fatty Acids
; 83(4-6): 219-23, 2010.
Article
en En
| MEDLINE
| ID: mdl-20719489
ABSTRACT
Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100g/kg fat (91 lardsoybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 204n-6, but not 226n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Triglicéridos
/
Grasas de la Dieta
/
Ácidos Grasos
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido