[Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients].

ABSTRACT

OBJECTIVE: To investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene and systemic lupus erythematosus in Chinese Han patients. METHODS: Forty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study, and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: No significant difference was found in the CC, CT, and TT genotype frequencies or in the C and T allele frequencies between the SLE patients and the normal controls. CONCLUSION: 1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.