CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.
Biochem Genet
; 49(3-4): 190-201, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21165767
ABSTRACT
Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA P = 0.045; GG + AG vs. AA P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antígenos CD
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Neoplasias del Sistema Nervioso Central
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Polimorfismo de Nucleótido Simple
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Glioma
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Biochem Genet
Año:
2011
Tipo del documento:
Article
País de afiliación:
China