[Utility of infliximab therapy in severe enterorrhagia associated with Crohn's disease. Report of three cases]. / Utilidad del tratamiento con infliximab en la enterorragia severa asociada a la enfermedad de Crohn. Experiencia de tres casos.
Gastroenterol Hepatol
; 34(1): 24-8, 2011 Jan.
Article
en Es
| MEDLINE
| ID: mdl-21168243
ABSTRACT
Severe lower gastrointestinal (GI) bleeding is an infrequent complication in Crohn's disease. We report the cases of three patients with Crohn's disease, localized in distinct areas, who developed severe enterorrhagia requiring multiple transfusions. All three patients responded favorably to infliximab administration, which resolved the life-threatening hemorrhages and avoided emergency surgical resection, which had seemed inevitable. Based on this clinical experience and a review of the literature comparing infliximab with other pharmacological options, we believe that this drug should be the treatment of choice in patients with Crohn's disease who develop severe lower gastrointestinal bleeding. This strategy can, in some cases, avoid surgery if the bleeding stops due to rapid healing of the deep mucosal lesions causing the hemorrhagic episode.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Crohn
/
Factor de Necrosis Tumoral alfa
/
Hemorragia Gastrointestinal
/
Anticuerpos Monoclonales
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Gastroenterol Hepatol
Año:
2011
Tipo del documento:
Article
País de afiliación:
España