(1R,6R)-1-Methyl-8-aza-spiro-[5.6]dodecan-7-one.
Acta Crystallogr Sect E Struct Rep Online
; 64(Pt 6): o1151, 2008 May 24.
Article
en En
| MEDLINE
| ID: mdl-21202659
ABSTRACT
The crystal structure of the title compound, C(12)H(21)NO, has been investigated to establish the absolute stereochemistry at position 1. The absolute stereochemistry at the quaternary centre at position 6 is established to be R using an asymmetric Birch reductive alkyl-ation reaction for which the stereochemical outcome is known. The crystal structure indicates the presence of two conformers of the bicyclic (1R,6R)-spiro-lactam ring system that differ in the conformation adopted by the six-membered ring. In one conformer, the meth-yl group adopts an axial position whereas in the other conformer, the same methyl group adopts an equatorial position. In both conformers, the seven-membered ring adopts a chair conformation. The two conformers of the bicyclic spiro-lactam are connected to each other via inter-molecular N-Hâ¯O hydrogen bonds forming a heterodimer. The asymmetric unit contains two such dimers.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Acta Crystallogr Sect E Struct Rep Online
Año:
2008
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda