HLA/KIR restraint of HIV: surviving the fittest.
Annu Rev Immunol
; 29: 295-317, 2011.
Article
en En
| MEDLINE
| ID: mdl-21219175
ABSTRACT
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in differential responses to the virus. Genome-wide association studies have convincingly shown that the HLA class I locus is the most significant host genetic contributor to the variation in HIV control, underscoring a central role for CD8 T cells in resistance to the virus. However, both genetic and functional data indicate that part of the HLA effect on HIV is due to interactions between KIR and HLA genes, also implicating natural killer cells in defense against viral infection and viral expansion prior to initiation of an adaptive response. We review the HLA and KIR associations with HIV disease and the progress that has been made in understanding the mechanisms that explain these associations.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Receptores KIR
/
Antígenos HLA
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos