Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
Eur J Neurol
; 18(8): 1085-9, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21219542
ABSTRACT
BACKGROUND:
Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.METHODS:
We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.RESULTS:
We were unable to replicate the association between LINGO1 variants and familial ET.CONCLUSIONS:
Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Temblor Esencial
/
Polimorfismo de Nucleótido Simple
/
Proteínas de la Membrana
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Neurol
Asunto de la revista:
NEUROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
España