Evolution of enzymatic mechanisms of resistance among beta-lactam antibiotics.
J Int Med Res
; 18 Suppl 4: 37D-47D, 1990.
Article
en En
| MEDLINE
| ID: mdl-2126509
ABSTRACT
Resistance to third-generation cephalosporins occurs as a result of either the production of high concentrations of chromosomal cephalosporinase or, increasingly, the presence of broad-spectrum plasmid-mediated beta-lactamases. Both cases represent the response of bacteria in the hospital setting to the selection pressure brought to bear by the use of these antibiotics. Continued evolution of the plasmid-mediated enzymes is occurring as new antibiotics are introduced, probably reflecting the process that began when the first beta-lactamase apparently evolved from the penicillin-binding proteins. beta-Lactamase inhibitors offer one approach to dealing with the evolution of resistance to previously beta-lactamase-stable antibiotics.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pseudomonas aeruginosa
/
Beta-Lactamasas
/
Enterobacteriaceae
/
Antibacterianos
Idioma:
En
Revista:
J Int Med Res
Año:
1990
Tipo del documento:
Article
País de afiliación:
Francia