Carcinogenicity of deoxycholate, a secondary bile acid.
Arch Toxicol
; 85(8): 863-71, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21267546
ABSTRACT
High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10 months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Grasas de la Dieta
/
Ácido Clorogénico
/
Neoplasias del Colon
/
Ácido Desoxicólico
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Toxicol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos