Sumoylation of vimentin354 is associated with PIAS3 inhibition of glioma cell migration.
Oncotarget
; 1(7): 620-7, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21317457
ABSTRACT
The invasive phenotype of glioblastoma multiforme (GBM) is a hallmark of malignant process, yet the molecular mechanisms that dictate this locally invasive behavior remain poorly understood. Over-expression of PIAS3 effectively changes cell shape and inhibits GBM cell migration. We focused on the molecular target(s) of PIAS3 stimulated sumoylation, which play an important role in the inhibition of GBM cell motility. Here we report, through the immunoprecipitation with SUMO1 antibody, followed by proteomic analysis, the identification of vimentin (vimentin354), a nuclear component in GBM cells, as the main target of sumoylation promoted by PIAS3.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vimentina
/
Neoplasias Encefálicas
/
Movimiento Celular
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Chaperonas Moleculares
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Proteínas Inhibidoras de STAT Activados
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Sumoilación
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Glioma
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Oncotarget
Año:
2010
Tipo del documento:
Article