Comparison of diagnostic accuracy of clinical measures of breast cancer-related lymphedema: area under the curve.
Arch Phys Med Rehabil
; 92(4): 603-10, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21440706
ABSTRACT
OBJECTIVE:
To compare diagnostic accuracy of measures of breast cancer-related lymphedema (BCRL).DESIGN:
Cross-sectional design comparing clinical measures with the criterion standard of previous diagnosis of BCRL.SETTING:
University of California San Francisco Translational Science Clinical Research Center.PARTICIPANTS:
Women older than 18 years and more than 6 months posttreatment for breast cancer (n=141; 70 with BCRL, 71 without BCRL).INTERVENTIONS:
Not applicable. MAIN OUTCOMEMEASURES:
Sensitivity, specificity, receiver operator characteristic curve, and area under the curve (AUC) were used to evaluate accuracy.RESULTS:
A total of 141 women were categorized as having (n=70) or not having (n=71) BCRL based on past diagnosis by a health care provider, which was used as the reference standard. Analyses of ROC curves for the continuous outcomes yielded AUC of .68 to .88 (P<.001); of the physical measures bioimpedance spectroscopy yielded the highest accuracy with an AUC of .88 (95% confidence interval, .80-.96) for women whose dominant arm was the affected arm. The lowest accuracy was found using the 2-cm diagnostic cutoff score to identify previously diagnosed BCRL (AUC, .54-.65).CONCLUSIONS:
Our findings support the use of bioimpedance spectroscopy in the assessment of existing BCRL. Refining diagnostic cutoff values may improve accuracy of diagnosis and warrant further investigation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Espectroscopía Dieléctrica
/
Linfedema
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Arch Phys Med Rehabil
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos