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Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety.
Richardson-Jones, Jesse W; Craige, Caryne P; Nguyen, Thanh H; Kung, Hank F; Gardier, Alain M; Dranovsky, Alex; David, Denis J; Guiard, Bruno P; Beck, Sheryl G; Hen, René; Leonardo, E David.
Afiliación
  • Richardson-Jones JW; Department of Psychiatry, Columbia University, New York, New York 10032, USA.
J Neurosci ; 31(16): 6008-18, 2011 Apr 20.
Article en En | MEDLINE | ID: mdl-21508226
Identifying the factors contributing to the etiology of anxiety and depression is critical for the development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both disorders. The inhibitory serotonin-1A (5-HT(1A)) receptor exists in two separate populations with distinct effects on serotonergic signaling: (1) an autoreceptor that limits 5-HT release throughout the brain and (2) a heteroreceptor that mediates inhibitory responses to released 5-HT. Traditional pharmacologic and transgenic strategies have not addressed the distinct roles of these two receptor populations. Here we use a recently developed genetic mouse system to independently manipulate 5-HT(1A) autoreceptor and heteroreceptor populations. We show that 5-HT(1A) autoreceptors act to affect anxiety-like behavior. In contrast, 5-HT(1A) heteroreceptors affect responses to forced swim stress, without effects on anxiety-like behavior. Together with our previously reported work, these results establish distinct roles for the two receptor populations, providing evidence that signaling through endogenous 5-HT(1A) autoreceptors is necessary and sufficient for the establishment of normal anxiety-like behavior.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ansiedad / Conducta Animal / Receptor de Serotonina 5-HT1A / Red Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ansiedad / Conducta Animal / Receptor de Serotonina 5-HT1A / Red Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos