The relationship of plasminogen activators and oncogenes to tumour invasion.

Gelister, J S; Boulos, P B; Gaffney, P J; Mahmoud, M; Lewin, M R

Gelister, J S; Boulos, P B; Gaffney, P J; Mahmoud, M; Lewin, M R.

Afiliación

Gelister JS; Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.

Eur J Surg Oncol ; 16(1): 54-9, 1990 Feb.

Article en En | MEDLINE | ID: mdl-2155139

ABSTRACT

ABSTRACT

Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.

Asunto(s)

Invasividad Neoplásica/fisiopatología; Oncogenes; Activadores Plasminogénicos/fisiología; División Celular; Transformación Celular Neoplásica/genética; Transformación Celular Neoplásica/metabolismo; Humanos; Metástasis de la Neoplasia; Fosfatidilinositol 4,5-Difosfato; Fosfatidilinositoles/metabolismo

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oncogenes / Activadores Plasminogénicos / Invasividad Neoplásica Límite: Humans Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 1990 Tipo del documento: Article

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