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Centromere protein F and survivin are associated with high risk and a poor prognosis in colorectal gastrointestinal stromal tumours.
Chen, Wen-Bin; Cheng, Xiao-Bin; Ding, Wei; Wang, Yang-Jing; Chen, Dong; Wang, Jin-Hai; Fei, Ru-Shan.
Afiliación
  • Chen WB; Department of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China. cwbin@hotmail.com
J Clin Pathol ; 64(9): 751-5, 2011 Sep.
Article en En | MEDLINE | ID: mdl-21613637
ABSTRACT

AIMS:

Colorectal gastrointestinal stromal tumours (GISTs) are considered to be tumours with a relatively poor prognosis. Few reports have been performed to investigate the mechanisms behind their malignant behaviour and to identify new therapeutic strategies for their treatment. The authors conducted this study to explore potential targets for the treatment of colorectal GISTs (CRGISTs).

METHODS:

In the current study, the authors focused on centromere protein F and survivin, two markers that are known to affect the malignant behaviour of other tumours. Expression of centromere protein F and survivin was detected through the immunohistochemical staining of paraffin-embedded tumour tissues and then scored. The relationship between the expression of the two markers and their clinical parameters was analysed. Associated Survival analysis was available based on follow-up information.

RESULTS:

The authors demonstrated for the first time that centromere protein F and survivin expression were significantly associated with high risk and a poor prognosis (p<0.05) in CRGISTs. The authors also found that centromere protein F expression was more prevalent in males (p=0.002).

CONCLUSIONS:

The results suggest that centromere protein F and survivin are malignant behaviour markers for CRGISTs. The expression of centromere protein F or survivin points to a poor clinical outcome. Interfering with centromere protein F and/or survivin expression might be a potentially therapeutic strategy for treating malignant CRGISTs.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Neoplasias Colorrectales / Tumores del Estroma Gastrointestinal / Proteínas Inhibidoras de la Apoptosis / Proteínas de Microfilamentos Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Clin Pathol Año: 2011 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Neoplasias Colorrectales / Tumores del Estroma Gastrointestinal / Proteínas Inhibidoras de la Apoptosis / Proteínas de Microfilamentos Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Clin Pathol Año: 2011 Tipo del documento: Article