N-Acylhydrazones as inhibitors of PDE10A.
Bioorg Med Chem Lett
; 21(14): 4155-9, 2011 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-21696955
ABSTRACT
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Fosfodiesterasa
/
Quinolinas
/
Hidrolasas Diéster Fosfóricas
/
Hidrazonas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos