Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation.
Prog Biophys Mol Biol
; 107(1): 169-82, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21729716
ABSTRACT
This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Líquidos Corporales
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Integración de Sistemas
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Homeostasis
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Modelos Biológicos
Límite:
Humans
Idioma:
En
Revista:
Prog Biophys Mol Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia