Electrochemical oxidation by square-wave potential pulses in the imitation of phenacetin to acetaminophen biotransformation.
Analyst
; 136(23): 5064-7, 2011 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-21984979
ABSTRACT
Electrochemistry in combination with mass spectrometry is emerging as a versatile analytical technique in the imitation of oxidative drug metabolism during the early stages of drug discovery and development. Here, we present electrochemical O-dealkylation of phenacetin to acetaminophen by square-wave potential pulses consisting of consecutive sub-second oxidation and reduction steps. This O-dealkylation could not be achieved by oxidation at constant potential or longer potential pulses because of the fast hydrolysis of the reactive intermediates. Electrochemical conversion by square-wave potential pulses can thus widen the scope of electrochemical synthesis of metabolites and imitation of in vivo drug metabolism.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenacetina
/
Técnicas Electroquímicas
/
Acetaminofén
Idioma:
En
Revista:
Analyst
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos