Bmp signaling exerts opposite effects on cardiac differentiation.
Circ Res
; 110(4): 578-87, 2012 Feb 17.
Article
en En
| MEDLINE
| ID: mdl-22247485
ABSTRACT
RATIONALE The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where Bmp signaling in vivo regulates myocardial differentiation has remained largely unanswered. OBJECTIVE:
To identify when and where Bmp signaling regulates cardiogenic differentiation. METHODS ANDRESULTS:
Here we have observed that in zebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation into cardiomyocytes. Bmp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiation. Surprisingly, Bmp signaling is actively repressed in differentiating myocardial cells. We identified the inhibitory Smad6a, which is expressed in the cardiac tissue, to be required to inhibit Bmp signaling and thereby promote expansion of the ventricular myocardium.CONCLUSION:
Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Transducción de Señal
/
Diferenciación Celular
/
Proteínas Morfogenéticas Óseas
/
Proteínas de Pez Cebra
/
Miocitos Cardíacos
/
Células Madre Embrionarias
/
Corazón
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Circ Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos