Behavioral investigation of mice with experimental autoimmune encephalomyelitis.
Arq Neuropsiquiatr
; 69(6): 938-42, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22297884
ABSTRACT
Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG(35-55) model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG(35-55) are probably subtle or absent.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Conducta Animal
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Modelos Animales de Enfermedad
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Encefalomielitis Autoinmune Experimental
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Memoria
Límite:
Animals
Idioma:
En
Revista:
Arq Neuropsiquiatr
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil