Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer.
J Neural Transm (Vienna)
; 119(8): 981-5, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22331304
ABSTRACT
Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ansiedad
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Autoanticuerpos
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Inmunoglobulina G
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Síndrome de la Persona Rígida
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Proteínas del Tejido Nervioso
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania