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Relative expression of TAp73 and ΔNp73 isoforms.
Conforti, Franco; Yang, Ai Li; Agostini, Massimiliano; Rufini, Alessandro; Tucci, Paola; Nicklison-Chirou, Maria Victoria; Grespi, Francesca; Velletri, Tania; Knight, Richard A; Melino, Gerry; Sayan, Berna S.
Afiliación
  • Conforti F; University of Southampton, Cancer Sciences Unit, Somers Cancer Research Building, Southampton, UK.
Aging (Albany NY) ; 4(3): 202-5, 2012 Mar.
Article en En | MEDLINE | ID: mdl-22388545
ABSTRACT
The transcription factor p73 belongs to the p53 family of tumour suppressors and similar to other family members, transcribed as different isoforms with opposing pro- and anti-apoptotic functions. Unlike p53, p73 mutations are extremely rare in cancers. Instead, the pro-apoptotic activities of transcriptionally active p73 isoforms are commonly inhibited by over-expression of the dominant negative p73 isoforms. Therefore the relative ratio of different p73 isoforms is critical for the cellular response to a chemotherapeutic agent. Here, we analysed the expression of N-terminal p73 isoforms in cell lines and mouse tissues. Our data showed that the transcriptionally competent TAp73 isoform is abundantly expressed in cancer cell lines compared to the dominant negative ΔNp73 isoform. Interestingly, we detected higher levels of ΔNp73 in some mouse tissues, suggesting that ΔNp73 may have a physiological role in these tissues.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Nucleares / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN Límite: Animals / Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2012 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Nucleares / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN Límite: Animals / Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2012 Tipo del documento: Article País de afiliación: Reino Unido