[Efficacy of rifaximine in small intestinal bacterial overgrowth syndrome in patients after cholecystectomy].
Ter Arkh
; 83(12): 68-73, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-22416449
ABSTRACT
AIM:
To define frequency of onset of small intestinal bacterial overgrowth syndrome (SIBOGS) in patients with postcholecystectomy syndrome (PCS); to substantiate necessity of microflora correction and assess efficacy of rifaximine in the doses 800 and 1200 mg/day. MATERIAL ANDMETHODS:
A breath hydrogen test (BHT) was made in 82 PCS patients. Rifaximine was given to 40 SIBOGS patients 20 of them received the drug in a dose 800 mg/day and 20--in a dose 1200 mg/day for 7 days. The efficacy was estimated by attenuation of the clinical symptoms and parameters of BHT.RESULTS:
SIBOGS was detected in 73% of PCS patients. This was an indication for antibacterial treatment. Rifaximine in a dose 800 mg/day failed to attenuate pain and to eliminate dyspeptic syndromes in some patients, BHT in them was not normal. Administration of rifaximine in a dose 1200 mg/day normalized BHT in 90% patients and eliminated clinical symptoms in most of the patients.CONCLUSION:
Rifaximine in a dose 1200 mg/day vs 800 mg/day in PCS patients with SIBOGS is more effective as it eliminates clinical symptoms and normalizes BHT.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rifamicinas
/
Síndrome del Asa Ciega
/
Síndrome Poscolecistectomía
/
Intestino Delgado
/
Antibacterianos
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Ter Arkh
Año:
2011
Tipo del documento:
Article