Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 protein.
J Virol
; 86(11): 6345-9, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22438547
ABSTRACT
We previously constructed a recombinant monoclonal antibody (rec-MAb 63P4) that detects immediate-early protein IE63 encoded by varicella-zoster virus (VZV) in the cytoplasm of productively infected cells. Here, we used ORF63 truncation mutants to map the rec-MAb 63P4 binding epitope to amino acids 141 to 150 of VZV IE63, a region not shared with other widely used anti-IE63 antibodies, and found that the recombinant antibody does not bind to the simian IE63 counterpart.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas del Envoltorio Viral
/
Proteínas Inmediatas-Precoces
/
Herpesvirus Humano 3
/
Epítopos de Linfocito B
/
Anticuerpos Monoclonales
/
Anticuerpos Antivirales
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos