Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms.
Opt Lett
; 37(7): 1193-5, 2012 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-22466192
ABSTRACT
Radiation from a linear accelerator induces Cherenkov emission in tissue, which has recently been shown to produce biochemical spectral signatures that can be interpreted to estimate tissue hemoglobin and oxygen saturation or molecular fluorescence from reporters. The Cherenkov optical light levels are in the range of 10(-6) to 10(-9) W/cm2, which limits the practical utility of the signal in routine radiation therapy monitoring. However, due to the fact that the radiation is pulsed, gated-acquisition of the signal allows detection in the presence of ambient lighting, as is demonstrated here. This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Análisis Espectral
/
Dosimetría por Película
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Monitoreo Fisiológico
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Opt Lett
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos