[DNA mutations associated to rifampicin or isoniazid resistance in M. tuberculosis clinical isolates from Sonora, Mexico]. / Mutaciones asociadas con resistencia a rifampicina o isoniazida en aislamientos clínicos de M. tuberculosis de Sonora, México.
Salud Publica Mex
; 54(2): 167-70, 2012.
Article
en Es
| MEDLINE
| ID: mdl-22535176
ABSTRACT
OBJECTIVE:
To perform the analysis of specific regions of the major genes associated with resistance to isoniazid or rifampin. MATERIALS ANDMETHODS:
Twenty two M. tuberculosis strains, isolated from human samples obtained in Sonora, Mexico. Specific primers for hotspots of the rpoB, katG, inhA genes and the ahpC-oxyR intergenic region were used. The purified PCR products were sequenced.RESULTS:
Mutations in the promoter of inhA, the ahpC-oxyR region, and codon 315 of katG and in 451 or 456 codons of rpoB, were identified.CONCLUSIONS:
Detection of mutations not previously reported requires further genotypic analysis of Mycobacterium tuberculosis isolates in Sonora.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rifampin
/
ADN Bacteriano
/
Isoniazida
/
Mutación
/
Mycobacterium tuberculosis
/
Antituberculosos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Mexico
Idioma:
Es
Revista:
Salud Publica Mex
Año:
2012
Tipo del documento:
Article