Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.
EMBO J
; 31(13): 2895-907, 2012 Jun 29.
Article
en En
| MEDLINE
| ID: mdl-22580825
ABSTRACT
Genetic analyses in Drosophila revealed a synergy between Notch and the pleiotropic transcription factor Mef2 (myocyte enhancer factor 2), which profoundly influences proliferation and metastasis. We show that these hyperproliferative and invasive Drosophila phenotypes are attributed to upregulation of eiger, a member of the tumour necrosis factor superfamily of ligands, and the consequent activation of Jun N-terminal kinase signalling, which in turn triggers the expression of the invasive marker MMP1. Expression studies in human breast tumour samples demonstrate correlation between Notch and Mef2 paralogues and support the notion that Notch-MEF2 synergy may be significant for modulating human mammary oncogenesis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Factores Reguladores Miogénicos
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Sistema de Señalización de MAP Quinasas
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Proteínas de Drosophila
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Proliferación Celular
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Drosophila melanogaster
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Receptores Notch
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
EMBO J
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos