(3ß,18ß,20ß)-N-Eth-oxy-carbonyl-methyl-3-nitrato-11-oxoolean-12-ene-29-carboxamide methanol monosolvate.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 4): o1229-30, 2012 Apr 01.
Article
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| MEDLINE
| ID: mdl-22606164
ABSTRACT
The title compound, C(34)H(52)N(2)O(7)·CH(4)O, is the methanol solvate of a difunctionalized derivative of the therapeutic agent 18ß-glycyrrhetinic acid, a penta-cyclic triterpene. The five six-membered rings of the glycyrrhetinic acid moiety show normal geometries, with four rings in chair conformations and the unsaturated ring in a half-chair conformation. This moiety is substituted by a nitrate ester group and an O-ethyl-glycine group. In the crystal, the nonsolvent mol-ecules are packed parallel to (010) in a herringbone fashion with the nitrato, ethyl-glycine and methanol-O atom being proximate. The methanol solvent mol-ecule is anchored via a donated O-Hâ¯O(ac-yl) and an accepted N-Hâ¯O hydrogen bond, giving rise to infinite zigzag chains of hydrogen bonds parallel to [100]. Two weak intermolecular C-Hâ¯O interactions to the methanol and to an acyl oxygen establish links along [100] and [010], respectively.
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01-internacional
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MEDLINE
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En
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Acta Crystallogr Sect E Struct Rep Online
Año:
2012
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Article