Influenza A viruses control expression of proviral human p53 isoforms p53ß and Delta133p53α.
J Virol
; 86(16): 8452-60, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22647703
ABSTRACT
Previous studies have described the role of p53 isoforms, including p53ß and Δ133p53α, in the modulation of the activity of full-length p53, which regulates cell fate. In the context of influenza virus infection, an interplay between influenza viruses and p53 has been described, with p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection by using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that infection differentially regulates the expressions of p53ß and Δ133p53α. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, with p53ß and Δ133p53α acting as regulators of viral production in a p53-dependent manner.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Regulación de la Expresión Génica
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Proteína p53 Supresora de Tumor
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Interacciones Huésped-Patógeno
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido