SET oncogene is upregulated in pediatric acute lymphoblastic leukemia.
Tumori
; 98(2): 252-6, 2012.
Article
en En
| MEDLINE
| ID: mdl-22677993
ABSTRACT
AIMS AND BACKGROUND:
The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors. METHODS AND STUDYDESIGN:
We determined the expression level of SET in 59 pediatric acute lymphoblastic leukemia patients who were BCR-ABL-negative using quantitative real-time reverse-transcriptase-polymerase chain reaction. Results. We showed that SET expression was significantly upregulated in 96.5% of B-acute lymphoblastic leukemia (28 of 29; 16.6 fold) and 93% of T-acute lymphoblastic leukemia (28 of 30; 47.6 fold) patients. This upregulation was not associated with any clinical features or overall and relapse-free survival.CONCLUSIONS:
Our results showed that SET is significantly overexpressed in pediatric acute lymphoblastic leukemia samples, and an increased level of SET might contribute to leukemic process.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Biomarcadores de Tumor
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Regulación Neoplásica de la Expresión Génica
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Regulación hacia Arriba
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Chaperonas de Histonas
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Tumori
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía