The optimization of pyridazinone series of glucan synthase inhibitors.
Bioorg Med Chem Lett
; 22(16): 5268-71, 2012 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-22818082
ABSTRACT
A detailed structure-activity relationship study of a novel series of pyridazine-based small molecule glucan synthase inhibitors is described. The optimization of the PK profile of this series led to the discovery of compound 11g, which demonstrated in vivo potency ip in a lethal fungal infection model.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridazinas
/
Sulfonamidas
/
Inhibidores Enzimáticos
/
Glucosiltransferasas
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos