Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis.
Lipids Health Dis
; 11: 92, 2012 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-22824324
ABSTRACT
The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3, aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. The major goal of this review is to highlight the modulation of each of the PONs by infective (bacterial, viral and parasitic) agents, which may shed a light on the interaction between infectious diseases and PONs activities in order to effectively reduce the risk of developing atherosclerosis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Parasitarias
/
Infecciones Bacterianas
/
Virosis
/
Arildialquilfosfatasa
/
Aterosclerosis
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Lipids Health Dis
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón