Establishing the principle of reversibility in peptide/protein and small-molecule therapy.
Ther Deliv
; 3(1): 17-23, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22833930
ABSTRACT
Several important pharmacological features can be integrated into injected drugs to enhance their therapeutic efficacy following administration. Short-lived peptide/protein drugs should be converted into long-lived species in vivo to avoid multiple injections. Circulating levels of anticancer agents need to be maintained within a narrow therapeutic range for prolonged period. Water-insoluble drugs must be turned into soluble species and blood-brain barrier-impermeable agents need to be modified to cross it following peripheral administrations. The derivatization requiring for achieving those desirable pharmacological features typically result in biologically/pharmacologically inactive products, unless those derivatizations can be carried out in a reversible fashion.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Proteínas
Límite:
Humans
Idioma:
En
Revista:
Ther Deliv
Año:
2012
Tipo del documento:
Article
País de afiliación:
Israel