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A porcine model of familial adenomatous polyposis.
Flisikowska, Tatiana; Merkl, Claudia; Landmann, Martina; Eser, Stefan; Rezaei, Nousin; Cui, Xinxin; Kurome, Mayuko; Zakhartchenko, Valeri; Kessler, Barbara; Wieland, Hagen; Rottmann, Oswald; Schmid, Roland M; Schneider, Günter; Kind, Alexander; Wolf, Eckhard; Saur, Dieter; Schnieke, Angelika.
Afiliación
  • Flisikowska T; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Merkl C; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Landmann M; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Eser S; Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
  • Rezaei N; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Cui X; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Kurome M; Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
  • Zakhartchenko V; Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
  • Kessler B; Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
  • Wieland H; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Rottmann O; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Schmid RM; Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
  • Schneider G; Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
  • Kind A; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
  • Wolf E; Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
  • Saur D; Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
  • Schnieke A; Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany. Electronic address: schnieke@wzw.tum.de.
Gastroenterology ; 143(5): 1173-1175.e7, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22864254
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate ß-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genes APC / Poliposis Adenomatosa del Colon / Modelos Animales de Enfermedad Límite: Animals / Humans / Male Idioma: En Revista: Gastroenterology Año: 2012 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genes APC / Poliposis Adenomatosa del Colon / Modelos Animales de Enfermedad Límite: Animals / Humans / Male Idioma: En Revista: Gastroenterology Año: 2012 Tipo del documento: Article País de afiliación: Alemania