Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.
Z Naturforsch C J Biosci
; 67(7-8): 375-80, 2012.
Article
en En
| MEDLINE
| ID: mdl-23016276
ABSTRACT
Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 < or = 100 microM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an alpha-exomethylene-gamma-lactone ring is necessary for these activities.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Inula
/
Lactonas
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Z Naturforsch C J Biosci
Año:
2012
Tipo del documento:
Article
País de afiliación:
China