Classification of thymoma by fine needle aspiration biopsy according to WHO classification: a cytological algorithm for stepwise analysis in the classification of thymoma.
Acta Cytol
; 56(5): 487-94, 2012.
Article
en En
| MEDLINE
| ID: mdl-23075888
ABSTRACT
OBJECTIVE:
To evaluate the cytological characteristics of each type of thymoma and introduce an algorithm to classify thymoma using fine needle aspiration biopsy (FNAB). STUDYDESIGN:
We retrospectively reviewed the cytological characteristics of 15 cases of thymoma with three thymic carcinoma (1 type A thymoma, 6 type AB thymomas and 8 type B thymomas), which were confirmed by histology. Three major and one minor cytomorphologic parameter were adopted for classification (1) number of lymphocytes in the smear background; (2) nuclear characteristics of thymic cells; (3) lymphocytes and crush artifacts in thymic cell clusters, and (4) nuclear arrangement of thymic cells.RESULTS:
An abundant lymphocytic smear background indicated type B thymomas in 87.5% of cases, contrary to the few lymphocytes in the remaining thymic tumors excluding type B thymomas (90%). Thymic cells contained no vesicular nuclei and inconspicuous nucleoli in 85.7% of type A thymoma and type AB thymoma cases. Type AB thymomas and type B thymomas showed more prominent crush artifacts in cell clusters than type A thymoma and thymic carcinoma. Thymic cells of type B thymomas and thymic carcinoma were arranged without whirling architecture in clusters. The proposed algorithm demonstrated a predictive rate of 88.8% for thymoma classification.CONCLUSIONS:
The stepwise classification of thymoma with FNAB may be useful in patients for whom an invasive diagnosis approach is not feasible.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timoma
/
Timo
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Neoplasias del Timo
/
Biopsia con Aguja Fina
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Cytol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Corea del Sur