Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids.
Steroids
; 78(1): 34-7, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23127817
ABSTRACT
19-Hydroxy-6-azapregnanes were obtained from pregnenolone via a 7-azido-5-oxo-6-nor-5,7-secopregnane intermediate. The 6-azapregnane core was built in good yield in a straightforward way from the secosteroid, by means of a Staudinger (aza-Wittig) reaction. Finally the 19-hydroxy-6-azapregnane was transformed into 19-hydroxy-6-azaprogesterone (that cyclized spontaneously to the 19â3 hemiketal) and 6-azaprogesterone. The 6-azapregnanes lacked agonistic/antagonistic activity on the progesterone receptor.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pregnanos
/
Progesterona
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Steroids
Año:
2013
Tipo del documento:
Article
País de afiliación:
Argentina