New triterpenoids with cytotoxic activity from actinidia valvata.

Qu, Li-Ping; Zheng, Guo-Yin; Su, Yong-Hua; Zhang, Hui-Qing; Yang, Yan-Long; Xin, Hai-Liang; Ling, Chang-Quan

Qu, Li-Ping; Zheng, Guo-Yin; Su, Yong-Hua; Zhang, Hui-Qing; Yang, Yan-Long; Xin, Hai-Liang; Ling, Chang-Quan.

Afiliación

Qu LP; Department of Traditional Chinese Medicine, Changhai Hospital of Second Military Medical University, Shanghai 200433, China. lingchangquan@gmail.com.

Int J Mol Sci ; 13(11): 14865-70, 2012 Nov 13.

Article en En | MEDLINE | ID: mdl-23203098

ABSTRACT

ABSTRACT

Two new triterpenoids, 30-O-beta-D-glucopyranosyloxy-2alpha,3alpha,24-trihydroxyurs-12,18-diene-28-oic acid O-beta-D-glucopyranosyl ester (1) and 2alpha,3beta,3,30-tetrahydroxyurs-12,18-diene-28-oic acid O-beta-D-glucopyranosyl ester (2) were isolated from roots of Actinidia valvata Dunn. Their structures were elucidated by means of extensive spectroscopic studies. Both these two new compounds showed moderate cytotoxic activity in vitro against BEL-7402 and SMMC-7721 tumor cell line.

Asunto(s)

Actinidia/química; Extractos Vegetales/química; Extractos Vegetales/toxicidad; Triterpenos/química; Triterpenos/toxicidad; Supervivencia Celular/efectos de los fármacos; Estructura Molecular; Resonancia Magnética Nuclear Biomolecular; Extractos Vegetales/aislamiento & purificación; Raíces de Plantas/química; Triterpenos/aislamiento & purificación

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triterpenos / Extractos Vegetales / Actinidia Idioma: En Revista: Int J Mol Sci Año: 2012 Tipo del documento: Article País de afiliación: China

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