SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.

Nagaria, Pratik; Svilar, David; Brown, Ashley R; Wang, Xiao-Hong; Sobol, Robert W; Wyatt, Michael D

Nagaria, Pratik; Svilar, David; Brown, Ashley R; Wang, Xiao-Hong; Sobol, Robert W; Wyatt, Michael D.

Afiliación

Nagaria P; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, United States.
Svilar D; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine & University of Pittsburgh Cancer Institute, Hillman Cancer Center, United States.
Brown AR; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine & University of Pittsburgh Cancer Institute, Hillman Cancer Center, United States.
Wang XH; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine & University of Pittsburgh Cancer Institute, Hillman Cancer Center, United States.
Sobol RW; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine & University of Pittsburgh Cancer Institute, Hillman Cancer Center, United States; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, United
Wyatt MD; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, United States. Electronic address: Wyatt@cop.sc.edu.

Mutat Res ; 743-744: 26-32, 2013.

Article en En | MEDLINE | ID: mdl-23253900

Asunto(s)

Replicación del ADN/efectos de los fármacos; Fluorouracilo/farmacología; Uracil-ADN Glicosidasa/genética; Uracil-ADN Glicosidasa/metabolismo; Puntos de Control del Ciclo Celular/efectos de los fármacos; Puntos de Control del Ciclo Celular/genética; Línea Celular; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1); ADN/biosíntesis; ADN/genética; Roturas del ADN de Doble Cadena/efectos de los fármacos; Replicación del ADN/genética; Técnicas de Silenciamiento del Gen; Humanos; Fosforilación/efectos de los fármacos; Fosforilación/genética; Proteínas Quinasas/genética; Proteínas Quinasas/metabolismo; Fase S/efectos de los fármacos; Fase S/genética; Uracilo/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Replicación del ADN / Uracil-ADN Glicosidasa / Fluorouracilo Límite: Humans Idioma: En Revista: Mutat Res Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos

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