[Molecular and genetic features of gastrointestinal stromal tumors (GIST)]. / Características genético-moleculares de los tumores estromales gastrointestinales (GIST).
Rev Gastroenterol Peru
; 32(4): 394-9, 2012.
Article
en Es
| MEDLINE
| ID: mdl-23307090
ABSTRACT
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms typically arising in the stomach, small intestine, colon, and other sites in the abdominal cavity and its identification has improved dramatically mainly due to better criteria in its detection. Most GISTs tumors harbor activating mutations in the tyrosine kinase receptor c-KIT or platelet derived growth factor receptor-alpha (PDGFRA). Those mutations are restricted to a few regions corresponding to important functional domains of c-KIT or PDGFRA. Upto 70% of cases are due to mutations in exon 11 of c-KIT corresponding to its juxtamembrane region of the receptor. The location and type of mutation will differentially determine the development of the disease, its prognosis and the response to inhibitors of tyrosine kinases as Imanatib. For this reason, genotyping c-KIT and PDGFRA is important for GIST diagnosis and assessment of sensitivity to tyrosine kinase inhibitors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Proteínas Proto-Oncogénicas c-kit
/
Receptor alfa de Factor de Crecimiento Derivado de Plaquetas
/
Tumores del Estroma Gastrointestinal
/
Neoplasias Gastrointestinales
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Es
Revista:
Rev Gastroenterol Peru
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2012
Tipo del documento:
Article