Reactions of nitric oxide and nitrogen dioxide with coenzyme Q: involvement of the isoprenic chain.
Org Biomol Chem
; 11(8): 1399-406, 2013 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-23334659
ABSTRACT
The formation of a di-tert-alkyl nitroxide has been observed by Electron Spin Resonance during the exposure of coenzyme CoQ(10), in both the oxidized and reduced forms, to nitrogen dioxide (ËNO(2)) or to nitric oxide (ËNO) in the presence of oxygen. The same kind of nitroxide has been observed also with CoQ(1), CoQ(3) or with 1-phenyl-3-methyl-2-butene, chosen as model compounds. In all cases, the formation of the nitroxide may be justified only by admitting the involvement of the isoprenic chain of the coenzymes and in particular the addition of ËNO(2) to the double bond. A mechanism which accounts for the formation of the nitroxide as well as the other compounds observed in the reactions is proposed and confirmed by a spectroscopic investigation (FT-IR, (1)H NMR, X-ray analysis) and by ESI-MS.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pentanos
/
Butadienos
/
Ubiquinona
/
Hemiterpenos
/
Óxido Nítrico
/
Dióxido de Nitrógeno
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia